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‘Molecular glues’ and ‘bumpers’ offer new hope for precision medicines

Tuesday, November 4th, 2025

New research led by the University of Minnesota Medical School demonstrates that molecules acting as “molecular bumpers” and “molecular glues” can rewire G protein-coupled receptor (GPCR) signaling, turning the cell’s busiest receptors into precision tools—opening the door to a new generation of safer, smarter medicines. The findings were published today in Nature.

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